4001百老汇净水

报告时间：2026年5月25日 星期一 下午15:00

报告地点：3号楼2楼报告厅

报告专家：Mary Mullins 教授 美国宾夕法尼亚大学

报告题目：Molecular mechanisms of germ layer formation and axis specification

Dr. Mary Mullins is a Professor and Vice Chair of the department of Cell and Developmental Biology at the University of Pennsylvania, Perelman School of Medicine, as well as the Assistant Dean for Junior Faculty Advancement. She graduated from the University of Wisconsin, Madison with a B.S. in Biochemistry and earned her PhD in Biochemistry from the University of California, Berkeley. She spent her postdoctoral years at the Max Planck Institute in Tübingen, Germany, under the advisory of 1995 Nobel Prize awardee Dr. Christiane Nüsslein-Volhard. She did pioneering postdoctoral work in developing and performing a large-scale forward genetic screen in the zebrafish that helped launch the zebrafish field. She began her independent career at the University of Pennsylvania thereafter. Her lab is studying the molecular mechanisms by which a BMP signaling pathway establishes the vertebrate body plan. Her lab has performed a large-scale maternal-effect mutant screen in the zebrafish, where she has identified a multitude of novel factors regulating oocyte polarity and the oocyte to embryo transition. She was elected as a Fellow of the American Association for the Advancement of Science in 2016, received the Christiane Nüsslein-Volhard Award for outstanding achievements in zebrafish research in 2023, and the George Streisinger Award in 2025 as one of the directors of the Zebrafish Development and Genetics Woods Hole course.

Mary Mullins博士是美国宾夕法尼亚大学佩雷尔曼医学院细胞与发育生物学系教授、国际斑马鱼学会前任主席。她本科毕业于威斯康星大学麦迪逊分校，获生物化学学士学位，后在加州大学伯克利分校取得生物化学博士学位。博士后期间，她在德国马普研究所师从1995年诺贝尔奖得主Christiane Nüsslein-Volhard（克里斯汀·纽斯林-沃尔哈德）博士。在此期间，她召开了开创性研究，参与设计并执行了斑马鱼领域首次大规模正向遗传筛选，这一工作极大地有助于了斑马鱼分子遗传学的开展。此后，她在宾夕法尼亚大学开启独立科研生涯。她的实验室致力于研究BMP信号通路调控脊椎动物胚胎发育命运决定的分子机制。其团队在斑马鱼中召开了大规模母源效应突变体筛选，鉴定出大量调控卵母细胞极性及母源-合子转换的新因子。她于2016年当选美国科学促进会会士（AAAS Fellow），2023年以表彰其在斑马鱼研究领域的杰出成就，荣获Christiane Nüsslein-Volhard奖，2025年作为伍兹霍尔斑马鱼发育与遗传学课程负责人之一，取得国际斑马鱼学会George Streisinger（乔治·施特雷辛格）大奖。在Cell, Nature Genetics, Nature Cell Biology, Developmental Cell, PNAS, Current Biology等主流学术期刊发表100多篇学术论文。

报告专家：Michael Granato 教授 美国宾夕法尼亚大学

报告题目：Molecular Mechanisms of Axon Guidance and Regeneration

Dr. Michael Granato is a Professor of Cell and Developmental Biology and a Professor of Neuroscience at the University of Pennsylvania. Dr. Granato graduated from the University of Tübingen, Germany where he earned his PhD in Biochemistry. For his postdoctoral work he  joined the lab of the 1995 Nobel Prize awardee Dr. Christiane Nüsslein-Volhard in Germany. After a highly productive postdoctoral period during which he published over 30 collaborative papers on a large-scale forward genetic screen that helped launch the zebrafish field, he started his own, independent research career at the University of Pennsylvania. Work in his lab focusses on various aspects of modern molecular and cellular neuroscience using zebrafish, including on axon guidance and synapse formation, and more recently on spontaneous CNS axon regeneration and autism relevant behaviors. His lab has performed large-scale mutant screens and small molecule screen that identified a multitude of genes and pathways previously not implicated in regulating CNS axon regeneration, habituation learning and sensorimotor decision making. He received the prestigious Humboldt Foundation F. W. Bessel Research Award from the German Government and the George Streisinger Award in 2025 as one of the directors of the Zebrafish Development and Genetics Woods Hole course.

Michael Granato 博士是美国宾夕法尼亚大学细胞与发育生物学教授兼神经科学教授。他博士毕业于德国图宾根大学，获生物化学博士学位。在博士后研究阶段，他加入1995年诺贝尔奖得主 Christiane Nüsslein-Volhard（克里斯汀·纽斯林-沃尔哈德）博士在德国的实验室。博士后期间，他合作发表论文超过30篇，主要参与一项大规模正向遗传筛选研究，该研究极大地有助于了斑马鱼领域的开展。此后，他在宾夕法尼亚大学开启独立科研生涯，其实验室致力于利用斑马鱼召开现代分子与细胞神经生物学研究，包括轴突导向、突触形成，以及近年来关注的中枢神经系统轴突自发再生和自闭症相关行为。他的团队顺利获得大规模突变体筛选和小分子筛选，鉴定出大量此前未知的基因与信号通路，这些通路在调控中枢神经系统轴突再生、习惯化学习以及感觉运动决策中发挥关键作用。他曾获德国政府颁发的享有盛誉的洪堡基金会弗里德里希·威廉·贝塞尔研究奖，并于2025年作为伍兹霍尔斑马鱼发育与遗传学课程的负责人之一，荣获国际斑马鱼学会 George Streisinger（乔治·施特雷辛格）大奖。在Neuron, Nature Neuroscience, PNAS等主流学术期刊发表100多篇论文。